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Ikuru Yoshizumi has spent the last decade of his life suffering from a terminal illness, and his death quickly approaches. Seeking a reason to carry on in his final days, Ikuru applies for ownership of an AGH-RMS, a genetically engineered human with a short lifespan, designed to provide comfort for those who are on their last legs. Ikuru is given Ai, an AGH-RMS who appears and functions as a girl his age. Ikuru finds his own reason for living within Ai, who is able to develop her own personality through her pure love for Ikuru. As unpreventable global conflict threatens the future of the human race, Ai and Ikuru cling to each other for safety and understanding. [Written by MAL Rewrite]

Haunted by a space flight accident that claimed the life of his beloved wife, Yuri finds himself six years later as part of a team of debris cleaners on a vessel called the Toy Box charged with clearing space junk from space flight paths. The team consists of Hachimaki, a hot shot debris-man with a sailor's affinity for the orbital ocean; Fee, a chain-smoking tomboy beauty with an abrasive edge; and Pops, a veteran orbital mechanic whose avuncular presence soothes the stress of the job. (Source: TokyoPop)

America in the Roaring 20s. On the surface, it's a positive, peaceful time after the violence of the Great War. But lurking in the shadows is a dark element ready to snatch that peace away. Sister Rosette Christopher, an exorcist working as a part of the Magdala Order, has a duty to fight the demons which appear and cause destruction. But along with her companion Chrno, she usually ends up causing more destruction than the demons themselves! On one particular mission, they meet a young girl with a beautiful voice named Azmaria, who is being targeted by her own stepfather. As Rosette and Chrno work to save her, more is revealed about the relationship between them. There is more to these two than meets the eye. (Source: ADV)

Jindai High School was a relatively safe place, right up until Sousuke Sagara transferred there. A total nut, he wreaks havoc on the school's student body and gets into a world of trouble with the teachers! But there's more to Sousuke than meets the eye—not just a hell-raising student, he's actually a member of an elite military unit, on an undercover mission to protect the beautiful schoolgirl Kaname Chidori from the KGB. (Source: TokyoPop)

Kaizou Katsu is a very gullible 17-year-old high school student who is a believer in science fiction, aliens, ghosts, UFOs, conspiracies, etc. He thinks that everything going on around him is the result of some sort of alien plot to take over the world. Each story is pretty much self-contained and is completely bizarre. Kaizou joins the school's science club, makes new friends, and ends up coming in contact with all sorts of strange things like log people, deadly sushi, pee-blades, scary infections, robot invasions, ghosts, living dolls, and more! Included one-shot: Volume 13: Yuuryou Bukken Chuukai Shimasu (A Brooding, Gloomy Property)

"From a dying planet shall come the children of light..." While on vacation on a small island, young Shiina Tamai dives under the water near an old shrine and discovers an unearthly starfish-like creature. She nearly drowns but is rescued by the silent, wide-eyed little animal, who Shiina befriends and names Hoshimaru. To Shiina's surprise and delight, the creature changes shape, lets Shiina stand on him, and the two fly off into the clouds. But what looks to be a young girl's ultimate fantasy soon takes a darker turn as Shiina and Hoshimaru become entangled in a struggle between rival extraterrestrial factions who battle in the skies upon huge alien beasts called Shadow Dragons, with the fate of Earth hanging in the balance. (Source: Dark Horse)

In the panic surrounding a worldwide pandemic which kills 15 percent of the population and cripples many more, a secret organization, the Propater, topples the UN and seizes control of much of the world. A boy and a girl, raised in an abandoned virology research center, immune to the virus, are attacked by the Propater and escape. Twenty years later, the boy is the most powerful drug lord in South America. He aids his son from behind the scenes as he evades and eventually with the help of mercenaries from Nomad (some of them former Propater operatives) fights the Propater. As the plot develops focus shifts away from the main character and develops many sub-plots dedicated to terrorism, Human-improvement, the struggle of the developing countries and the power battles between the drug cartels and Propater. Based strongly on Gnostic mythology, all major characters are named after gnostic deities, and have analogous roles. (Source: MU)

In an enormous steel labyrinth riddled with horrifying creatures, humanity is forced to isolate itself in small enclaves while living in constant fear of its annihilation. In this dystopia, only a strange young man known as Killy is brave enough to traverse its unforgiving territories. Possessing superhuman strength and a rare Graviton Beam Emitter, Killy fights off bloodthirsty beasts and other fiendish forces in his desperate search for a human with the Net Terminal Gene—genetic information that holds the potential to restore the corrupt world. The dark world of Blame! follows Killy as he meets new people, sheds more blood, and draws closer to finding the Net Terminal Gene. Through these exploits, the true nature of the world is slowly pieced together. [Written by MAL Rewrite]

In the present day, hundreds of extraterrestrial species walk the Earth. Some are pacifistic, others violent. Some are here for research purposes, others are career criminals. However, humans don't know they are here. Now, one more alien has arrived on Earth. One of the universe's foremost geniuses with a personality that's bound to attract all sorts of trouble. (Source: AniDB)

Much of the damage attributed to "Vash" is caused by the activities of bounty hunters who are after the 60,000,000,000$$ (sixty billion "double dollars") reward on Vash's head for the destruction of a city called July. Vash does not clearly remember the destruction of July, and only wants "love and peace," as he puts it; though he is a gunfighter of inhuman skill, he uses his weapons only to save lives wherever he can. As the series progresses, more is gradually learned about Vash's mysterious history and the history of the human civilization on Gunsmoke, the desert planet the series is set on. The series is often humorous in tone, but at the same time it involves very serious character development and especially in later episodes it becomes quite emotionally intense. Vash is occasionally joined by a priest, Nicholas D. Wolfwood, who is almost as good a gunfighter as Vash himself, and later is targeted by a band of assassins known as the Gung-Ho Guns for reasons which are mysterious at first. Trigun evolves into a very serious discussion of the nature of morality, posing questions such as: What is the nature of morality? Can we judge different moral codes? If a person is forced to betray their moral code, does that betrayal invalidate that moral code, and can the person still try to live up to that moral code? Can the person find redemption from their wrongs, and if so, how? (Source: Wikipedia) Included one-shot: Volume 2: Trigun (pilot)

In 1999, a meteorite crashed into Antarctica. The impact melted the continental ice mass and drastically raised sea levels, damaging the world's climate and causing the deaths of over half its population. Now in 2015, devastating creatures of unknown origin—referred to as Angels—ravage what remains of the planet. In the heavily fortified city of Tokyo-3, 14-year-old Shinji Ikari is destined to halt the Angels' onslaught. Recruited by his father's secret organization, NERV, Shinji is enlisted as a pilot of an Evangelion, a massive bioorganic android created solely to defeat the Angels. Suddenly with the weight of the world upon his shoulders, Shinji must find the courage and drive to stand up for the future—and himself. But as skirmishes between the Evangelions and Angels become recurrent, the horrifying truth of the world is slowly revealed. [Written by MAL Rewrite]

In a post-apocalyptic world where an environmental disaster led to the eruption of Mt. Fuji and the inundation of Yokohama, the age of humans is in its twilight. Alpha Hatsuseno is an android and the namesake of a small cafe outside Yokohama. As her owner is away on a trip indefinitely, she has been left responsible for running the cafe. Although she rarely gets any customers, Alpha remains outgoing and cheerful. While Alpha awaits her owner's homecoming, she explores the vicinity with her scooter and camera. Throughout her journeys, she meets new people and other androids, making memories along the way. Yokohama Kaidashi Kikou is a beautiful, laid-back story centered around Alpha's daily activities, emphasizing the passing of time in everyday life. [Written by MAL Rewrite]

The utopian metropolis of Zalem soars high in the skies, its presence dominating the horizon. Beneath it is the noxious underbelly known as The Scrapyard, where the city stockpiles all of its waste. Living amongst the vast heaps of garbage are humans and cyborgs, surviving by any means necessary. Daisuke Ido, a doctor specializing in cyborg repairs, finds the head of a young female cyborg while scavenging a pile of old android parts. Proceeding to build her a new body, he names her Gally. Upon activation, Gally does not seem to remember anything about her past life. Nonetheless, she does not seem to mind as long as she stays by Ido’s side. However, she soon discovers that Ido has a side job as a hunter-warrior, a bounty hunter working for The Scrapyard’s government. Despite Ido’s warning, she decides to become one herself, awakening her forgotten knowledge of fighting techniques. Equipped with newfound strength, Gally is determined to fight through the alleys of The Scrapyard and beyond, retrieving fragments from her past to rediscover her true identity. [Written by MAL Rewrite]

The story is set in a place very similar in appearance to Earth in the Edo period. However, Adachi (the mangaka) regularly reminds the reader all throughout the series that the setting is another planet in the distant future which just happens to look like Earth. After the death of his mother, Shichimi sets out to join his step-brothers and -sister who live together in Karakuri Tenement, a place provided by the father they have never met. He finds out that each of them had different mothers (all of whom have died), but were fathered by the same man. Not long after Shichimi's arrival, the siblings decide to journey to visit the graves of each of their mothers. On this journey, they encounter many dangers. (Source: Wikipedia)

High school student Youta Moteuchi is so unpopular that his classmates have given him the nickname "Dateless." So it's no surprise when the love of his life, Moemi, is not interested in Youta but instead is in love with Youta's best friend, Takashi. Youta turns to a video rental shop for comfort, but little did he suspect that the shop was magical and that the cute girl on his rented tape would pop out of the television and try to fix his ruined love life! (Source: VIZ Media) Included one-shot: Volume 15: Video Girl (pilot)

"Parasites" are tennis ball sized creatures, whose numbers and origins are unknown. They invade and take over the human mind in order to survive. Shinichi Izumi is a 16-year-old high school student who lives with his parents in a quiet neighborhood. One night, a Parasite invades Shinichi's body in an attempt to take control of it. However, it fails to complete the takeover process and ultimately ends up inhabiting only his right arm. Thus, both Shinichi and the Parasite—who calls himself Migi—retain their individual minds. Now in a peculiar "human and alien" relationship, Migi proposes that they cooperate to survive. Shinichi has no choice but to agree, and he must now cling to his morality as he and Migi face off against other bloodthirsty Parasites. [Written by MAL Rewrite]

The year is 2029. The world has endured four world wars and ushered in a new age of technological advancement that has largely transformed society as humanity knows it. Cybernetic enhancements, robotic AIs, and cyborgs have now become the norm in a world where humans are more machine than man. However, with this modern change, crime started evolving as well: hackers, corrupt officials, and other opportunists have found ways to sneak into innovative systems for their own personal agendas. In Japan, where such crimes run rampant, the government establishes Section 9—a clandestine team of highly trained operatives—to counter these threats. Major Motoko Kusanagi, a woman of impenetrable caliber and bravado, leads Section 9 on its mission to tackle cyberterrorism and ensure that the nation's stability does not falter in the pace of the rapidly progressing future. [Written by MAL Rewrite]

Faithful to the novels aside for some changes that may be considered major e.g. characters changed from male to female.

One day, a wanderer appears out of the wasteland to bring justice to the guilty and hope to the people—a warrior named Ken, a man who bears seven scars upon his chest and holds the secret of a mysterious martial art known as Hokuto Shinken, the Divine Fist of the North Star! (Source: VIZ Media)

1988: It is World War III. Tokyo is decimated by a mysterious black explosion, unmatched in magnitude. 2019: Fast forward 31 years. Neo-Tokyo, hastily built on the ruins of old Tokyo, is a sprawling cityscape of neon extravaganza. It is a fusion of towering skyscrapers and cutting-edge technology that is permeated through and through with an explosive, hyper-violent cocktail of biker gangs, poverty, and revolutionaries. In this derelict metropolis live Tetsuo Shima and Shoutarou Kaneda, two bikers who are the best of friends and the fiercest of rivals, despite being affiliated with the same gang. Desperate to prove himself as Kaneda's equal, Tetsuo unwittingly pulls a stunt that culminates in the awakening of a cryptic existence that threatens to change both the face of Neo-Tokyo and the lives of those who call the city their home—the awakening of a government secret simply known as Akira. [Written by MAL Rewrite]

In the far future, two young military leaders rise above their peers. The invincible genius Reinhard von Lohengramm is matched only by the unbeatable magician Yang Wen-li; though the two share a profound respect for each other, they meet on the battlefield not as comrades but as bitter adversaries. Commanding thousands of warships and millions of soldiers, they lead giant space fleets into battle on behalf of the two interstellar states that have wrested for control of the Milky Way for over a century and a half. The Galactic Empire, an absolute monarchy ruled by Kaiser Friedrich von Goldenbaum IV and an entrenched nobility, seeks to suppress the rebels daring to oppose the inviolable crown. The Free Planets Alliance, a representative democracy led by a corrupt High Council, degenerates as its elected leaders⁠ use war and conflict as a way to win popular support. Reinhard is a minor noble who became a High Admiral through his strategic brilliance and his sister's position as the favored concubine of the Kaiser, while Yang is an avid historian and reluctant commodore hailed as a hero despite only using his tactical prowess to navigate around his leaders' incompetence. On opposite sides of the galaxy, the two men have wildly different visions for the future: Reinhard dreams of uniting mankind under his iron fist, while Yang wants only to carve a path to lasting peace. As the war rages on, Reinhard and Yang each strive for their ideals and secure their place among the stars as the leaders of a new era of galactic heroes. [Written by MAL Rewrite]

When goofy inventor Senbei Norimaki creates a precocious robot named Arale, his masterpiece turns out to be more than he bargained for! Basking in the glow of his scientific achievement, Senbei scrambles to get Arale in working order so the rest of Penguin Village won't have reason to suspect she's not really a girl. But first Senbei needs to find her a pair of glasses and some clothes... (Source: VIZ Media)

What would you do if a tiger skin bikini-clad alien followed you to school every day? Poor Ataru's life has never returned to normal since volatile extraterrestrial princess Lum fell for him. Now an excruciatingly wealthy and genteel rival, Mendo, adds to Ataru's torment. Not to mention an unending stream of extraordinary classroom visitors and educational materials including incompetent cherry blossom spirits, a legendary nightmare-eating tapir, and a fourth-dimensional camera that breaches alternate realities. (Source: VIZ Media)

In the far future, humans have destroyed their homeplanet, Terra, by carelessly messing with the environment. In order to preserve the life of their homeland, Terra, humans have evacuated this world in order to spread life unto other planets. Humanity, now ruled by a super computer that controls the birth of children, sees the emergence of a new human race called the "Mu," whose telepathic powers have alarmed the System running all of humanity. The Mu, now hidden from the rest of humanity, have one dream, to return home, to Terra... (Source: ANN)